July - September
Advanced
Nutritional Supplement for Diabetics
Clinically Proven to Improve
Impaired Glucose Tolerance and
Hyperinsulinemia
Diabetes is a major health
concern in this country with $92
billion dollars being spent annually
for health care. According to the
National Diabetes Association, 16
million people in the U.S. have
diabetes and less than 1/2 aren't' t
even aware that they have it.
Diabetes ranks as the number 4 cause
death in America with 178,000
associated deaths annually. 18 -
24,000 people lose their eyesight
and more than 20,000 diabetics are
treated for renal disease. Diabetes
is the most frequent cause of non-
traumatic loss of limbs each year.
Clinical conditions of diabetes are
excessive thirst, frequent urination
in large volume, unusual weight
loss, blurred vision, high levels of
glucose and increased hydrogen ions.
The two types of diabetes are TYPE I
(IDDM, or insulin dependant), often
called juvenile diabetes, and TYPE
II (non- insulin dependant) or adult
onset diabetes with blood insulin
concentration being elevated.
TYPE I makes up 10% of the cases
with the majority being TYPE II.
TYPE II diabetics are not able to
move glucose into the muscle and fat
cells which consist of more than 60%
of total body cells. Fortunately,
research in this area using natural
medicines, diet and exercise is
growing rapidly. Controlling TYPE II
diabetes is now possible with the
new formula exclusively available
from PHP®.
This formula, PRO Z- GL, is a
patented formula ( patent # 5, 411,
748), backed by a double blind
study. PRO Z- GL was developed by
Dr. M.K. Song, a medical research
scientist from the UCLA Medical
Center. Dr. Song has been engaged in
the study of intestinal zinc
absorption mechanisms and the
clinical implications of altered
zinc absorption for more than 20
years, with over 70 published papers
to his credit.
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Current
Knowledge on Zinc and It' s
Influence on Clinical Manifestation
on Diabetes
Zinc is involved in almost all
disease states and health problems.
It activates over 300 metallo-
enzymes, including nucleic acid
polymerases (cell growth and
repair), super oxide dismutase
(antioxidant), peptidase (protein
digestion), alkaline phosphates, and
lactic and alcohol dehydrase. It has
been well documented that zinc plays
a key role in the regulation of
insulin production by the pancreas
and glucose utilization by muscle
and fat cells.
Zinc deficiency causes reduction or
inhibition of the insulin
manufacturing process in the
pancreas, because cells cannot
synthesize protein under zinc
deficient conditions and this often
causes gene mutation. More
importantly, the ability to utilize
glucose by the organ cells is
impaired in the zinc deficient
state. It has been proven that zinc
stimulates glucose transporter
translocation from inside cells
toward the membranes so that glucose
uptake by the cells is increased.
It is equally important to know that
the zinc metabolic cycle is only 5
hours long and most of the
metabolized zinc is excreted back
through the small and large
intestines. PRO Z- GL is a unique,
patented formula containing 100 mg
of amino acid chelated zinc, bovine
prostate powder, chromium and
inositol in a base of lecithin and
safflower oil.
The known chemical constituents
which affect the intestinal zinc
absorption mechanisms are:
protaglandins, citric acid,
picolinic acid, metallothionein
metabolites, L- histidine,
arachidonic acid and cyclo- HisPro.
Cyclo- HisPro is a major thyrotropin-
releasing hormone metabolite and is
present in large quantities in the
prostate and requires zinc for its
synthesis.
These zinc absorption agents are
richly packed into the prostate.
Animal prostate extract has been
recently identified as the most
powerful zinc absorption stimulator.
It appears as though all of these
constituents contained in the
prostate may act synergistically to
regulate zinc metabolism in the
organ cells of diabetics. Further,
PRO Z- GL contains 300 mg of
prostate substance.
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Effects of Bovine Prostate
Powder on Zinc, Glucose and Insulin
Metabolism in Aged Patients With
Non– insulin Dependent Diabetes
In a recent double– blind study
conducted at the Sepulveda
Department of Veterans Affairs (DVA)
Medical Center in California, 48 men
with type II diabetes, ages 60 to 75
were recruited. Twenty five were
assigned to the PRO Z - GL test
group, and 23 were given placebos.
Each was asked to eat a high
carbohydrate diet for at three days
prior to glucose testing.
PRO Z -GL was administered 4 times
daily for three months. In the group
of patients who had demonstrated
elevated blood glucose levels,
results showed a decrease in blood
glucose levels compared to levels
prior to treatment.
Both blood and HbAc and TAFGC levels
in all patients,who were given PRO
Z-GL,decreased significantly. Plasma
insulin levels decreased 27.6 % and
urinary glucose concentrations were
less than one third compared to
those found in the pre– treatment
group. Interestingly, both LDL and
total blood cholesterol levels
decreased with marginal significance
in those given PRO Z-GL.
PRO Z -GL improves glucose
tolerance, and reduces blood glucose
and HbA?c levels causing plasma
insulin levels to decrease. Since
zinc acts like insulin in the
absence of insulin, PRO Z-GL is also
expected to be a strong type I
diabetes formula.
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OSSEOAPATITE PLUS
Research shows that calcium
alone is not enough for the
treatment of bone loss.
Osteoporosis is the most common
metabolic bone disease in the U.S.
affecting over 25 million Americans
and accounting for 1.2 million bone
fractures per year. Osteoporosis in
women typically starts in the mid-
30's with a bone loss rate of about
1% per year.
In menopause, bone loss accelerates
to 3-5% per year for 5 years after
which bone loss continues at a 1.5%
rate per year. Current management of
osteoporosis focuses on estrogen and
calcium supplementation. Numerous
studies have shown that although
estrogen retards bone loss, it does
not completely prevent it and the
benefits must be weighed against its
risk of increased incidence of
endometrial cancer. Calcium
supplements in the dosage of 800-
1,500 mg per day play an important
role in prevention and treatment of
bone loss. However, it is clear that
calcium alone is not enough.
With this research in mind, PHP® has
added another superior calcium
complex to its nutraceutical
products division to fight against
Osteoporosis. Osseoapatite Plus
(TOSP) is available in a bottle of
90 or 225 tablets. One tablet
includes: Mycrocystalline
Hydroxyapatite (MCHC) (500mg),
Calcium (312mg) from New Zealand
calf bone concentrate of bone tissue
matrix. In clinical studies, MCHC is
better absorbed than other forms of
calcium and has been shown to
accelerate fracture healing2 and
improve or prevent osteoporosis.3
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Progesterone
and Bone Loss
Progesterone is a hormone
secreted by the corpus luteum
starting prior to ovulation and
increasing rapidly after ovulation
in menstruating women. Progesterone
is also made in smaller amounts by
the adrenal glands in both sexes and
by the testes in male, which is an
important step in the bio-synthesis
of adrenal cortical hormones.
Progesterone serves many functions
in the body: it helps normalize
blood sugar levels, zinc and copper
levels, helps restore proper oxygen
levels, protects against endometrial
cancer, helps normalize thyroid
hormone action and stimulates
osteoblast-mediated bone building,
to name a few. Bone mass is
relatively constant from puberty to
several years before menopause by
the balance of osteoclast function
(re-absorption of old bone) and
osteoblast function (formation of
new bone). If these two processes
are in balance, bone mass and bone
strength remain constant.
Osteoporosis is bone mass loss as
the result of osteoclast dominance,
i.e. more osteoclast- mediated bone
reabsorption than osteoblast-
mediated new bone formation occurs.
Dr. John Lee, MD has shown that by
adding natural progesterone to an
osteoporosis treatment program that
bone density can be increased up to
10% within the first six months.(1)
Dr. Lee has conducted a study
involving 100 post menopausal women
ranging in age 38- 83. The majority
had already lost height from the
disease, some as much as 5 inches.
After starting the program, patients
were followed for three years. Bone
loss density was measured using
serial dual photon absorptiometry.
The results were quite remarkable;
all but three women showed
improvement in the first six months.
Many women in this study noticed the
incidence of fractures dropping to
zero, with height stabilizing and
increased energy, their sex drive
returned to normal and they
experienced more joint mobility and
less aches and pains.(2)
Although progesterone plays a major
role in osteoporosis, other factors
are also important.
Dr. Lee recommends the following
treatment program for osteoporosis :
- A diet rich in green leafy
vegetables with red meat limited
to a few times per week.
- Elimination of sodas and
cigarettes!
- A daily nutritional
supplement of vitamin D 350-400
IU per day, vitamin C 2,000mg
per day, Betacarotene 15mg per
day, Zinc 15-30mg per day,
Calcium 800-1,000mg per day and
Magnesium 300 mg per day.
Patients in the above study were
asked to exercise 12- 20 minutes
daily or 1/2 hour 3 times per week.
- Natural progesterone cream
was applied daily at bedtime for
12 days a month. Those women on
estrogen were asked to apply the
cream during the last two weeks
of the month of estrogen use or
apply 3 weeks per month for 3
months.
Strong bone formation is an
important factor in progesterone
production and the use of
Progesterone-2 cream and
Osseoapatite Plus formula in pre-
and post- menopausal women is an
essential factor in the prevention
and proper treatment of
osteoporosis.
PHP's Progesterone- 2
cream contains : 1,200 mg
of natural progesterone per 2 oz.
tube.
There are 48 doses per tube at 100
mg per tsp. (or 25 mg per 1/4 tsp.,
the suggested dose.)
Please refer to the
directions on the tube for
applications.
References:
1:( Lancet 90;336(8726):1327)
2: John R. Lee, MD, Internal
Clinical Nutrition Review
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Product Announcement:
Pro
Magnesium/ Potassium Aspartate
At PHP, we have recognized the
need for a formula which helps
reduce the over-acidic nature of the
body. Cell integrity is maintained
by acheiving an acid-alkaline
balance in the body. Aspartic acid
is a non essential amino acid
employed to form mineral salts such
as potassium, magnesium and calcium
aspartate. Since aspartates are
easily absorbed, they can actively
transport these minerals across the
intestinal lining into the blood and
then into the cells where the can be
used in functions such as energy
production and support of bone
metabolism. Magnesium aspartate and
Potassium aspartate as mineral
transporters have the best
percentage of absorption and
bioavailability among all types of
magnesium and potassium.
Magnesium has many essential
metabolic functions in the body.
About 60% of the body' s magnesium
is stored in the skeletal system
with the remaining 40% found in
blood, fluids and other tissues, the
highest concentration being found in
the brain. It is involved in
hundreds of enzymatic reactions and
is of major importance in the
production and transfer of energy.,
muscle contraction and relaxation,
nerve impulse conduction, protein
synthesis and in aiding dilation and
constriction of the coronary
arteries.
Potassium is essential in
cellular biochemical reactions and
energy metabolism. Along with
Sodium, it regulates the water
balance and acid/ alkaline balance
in the blood. There are about 120
grams of Potassium in the body-
ninety eight percent of that is
found in the cell, where Potassium
is the primary positive ion. The
functions it serves include CO2
transport, nerve impulse conduction,
carbohydrate metabolism, activity in
glycogen and glucose metabolism, and
it is necessary for normal growth
and the building of muscles.
Magnesium and Potassium are both
intercellular minerals. Magnesium is
needed to help maintain potassium in
the cell. Potassium. along with
Magnesium, is needed to regulate the
excitability of muscle tissue, and
the conduction of nerve impulses
especially in cardiac muscles. As
fatigue is the most common symptom
in Potassium and/or Magnesium
deficiency, this combination can be
used to increase the available
energy for the body. By utilizing
the measurements of pH, redox, and
resistivity through Biological
Terrain Assessment, the majority of
patients monitored fall into the
category of metabolic acidosis and
benefit greatly from the buffering
capacity of the aspartated mineral
combination available from PHP. MMKA
(Magnesium/ Potassium Aspartate)
contains 432 mg of Magnesium and
Potassium Aspartate and 48mg of
Elemental Potassium in each capsule.
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